| Round Of 32 | Sweet 16 | Quarter Finals | Semi-Finals | Final | Champion | |
| | FC Providence Athletico - 0 | Lehigh Valley United Elite '00 - 0 | Lower Merion Sabertooth Rats - 3 | Lower Merion Sabertooth Rats - 1 | Lower Merion Sabertooth Rats | |
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| 4/12/2016 7:00 PM #112 - Salisbury | |
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| | 4/17/2016 12:00 PM #101 - Lehigh University C | |
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| Lehigh Valley United Elite '00 - 1 | |
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| | Lower Merion Sabertooth Rats - 3 | 5/1/2016 4:45 PM #105 - Overtime | |
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| 4/10/2016 4:30 PM #110 - Rosemont College | |
| | |
| | Lower Merion Sabertooth Rats - 4 | |
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| Penn United Force '00 - 1 | |
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| | YMS Premier Celtic '00 - 3 | YMS Premier Celtic '00 - 2 | 5/15/2016 12:30 PM #107 - United Sports #10 | |
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| 4/10/2016 12:15 PM #111 - Macclesfield C | |
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| | 4/16/2016 9:00 AM #102 - Macclesfield C | |
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| Penn Legacy Black '00 - 0 | |
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| | Ukrainian Nationals Chornomorets - 2 | YMS Premier Celtic '00 - 2 | |
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| 4/10/2016 12:30 PM #109 - PWHS - Victory 4 | |
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| | Ukrainian Nationals Chornomorets - 1 | |
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| FC Europa '00 - 0 | |
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| | FC Revolution Santos - 5 | FC Revolution Santos - 0 | Penn Fusion Elite '00 - 1 | |
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| 4/8/2016 7:30 PM #108 - Don Thomas Stadium | |
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| FC Pocono '00 - 0 | 4/17/2016 2:00 PM #104 - Overtime | |
| 4/3/2016 12:00 PM #114 - Minisink Park | |
| Continetal FC Premier '00 - 0 | |
| Continetal FC Premier '00 - 3 | |
| | Penn Fusion Elite '00 - 3 | 5/1/2016 1:00 PM #106 - West Chester #1 | |
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| 4/10/2016 1:30 PM #116 - WCU Rockwell Field | |
| | |
| | Penn Fusion Elite '00 - 1 | |
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| 1776 United '00 - 1 | |
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| | HMMS Eagle FC Titans '00 - 3 | HMMS Eagle FC Titans '00 - 1 | Penn Fusion Elite '00 - 0 | |
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| 4/10/2016 3:00 PM #115 - In The Net Outdoor | |
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| | 4/17/2016 11:00 AM #103 - Hidden Creek 1 | |
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| Warrington Union - 1 | |
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| CASA CAPA 2K United - 3 | CASA CAPA 2K United - 0 | HMMS Eagle FC Titans '00 - 0 | |
| 4/2/2016 4:00 PM #113 - George 1 | |
| 4/16/2016 8:00 AM #117 - George 1 | |
| PSC Coppa Crunch - 1 | |
| | PA Classics Elite '00 - 0 | |
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| PA Classics Elite '00 - 1 | |
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